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[Progression toward type-2 diabetes mellitus among Mexican pre-diabetics.
Assessment of a cohort]
BACKGROUND: Pre-diabetic Latino subjects have shown higher incidence of type 2 diabetes mellitus (DM2) compared with other populations. The incidence is unknown in the Mexican population. Our aim was to identify the annual incidence of DM2 among a Mexican pre-diabetic population. METHODS: An inception cohort of healthy Mexican patients was followed from 2001 to 2006. Those who fulfilled diagnosis of DM2 (ADA criteria) were registered at one and 2 years of follow-up among pre-diabetic and normoglucemic individuals. We compared relevant variables between both groups, those who developed diabetes and those who did not. RESULTS: 656 subjects were included; at one year, 14 patients were diagnosed with DM2, 11 among pre-diabetics, incidence of 4.5 %; 3 among normoglucemic subjects, incidence of 0.72 %. The relative risk for the development of DM2 in the pre-diabetic group was 7.7 (IC95 % 2.1-27.9), and among the normoglucemic group of 1.04 (IC95 % 1.02-1.08). At the 2nd year, DM2 incidence was 7.6 % in pre-diabetics, and 0.6 % in normoglucemics. Risk factors associated were higher fast glucose and greater BMI. CONCLUSIONS: We found a constant annual incidence of DM2 among prediabetics of 6 cases per 100 patient/year in follow-up. Higher fast glucose determinations and greater BMI are the main determinants for DM2 development. |
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Autoren:
Coronado-Malagon, Martin
; Gomez-Vargas, J Ivan
; Espinoza-Peralta, Diego
; Arce-Salinas, Alejandro
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Quelle:
Gac Med Mex. 2009 Jul-Aug;145(4):269-72.
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| Literaturrecherche: U.S.National Library of Medicine's PubMed® | |
 
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