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| NEUE FORSCHUNGSERGEBNISSE | |
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Higher Fibrinogen Levels Predict Progression of Coronary Artery Calcification in
Adults with Type 1 Diabetes.
AIM: To determine whether fibrinogen levels predict independently progression of coronary artery calcification (CAC) in adults with type 1 diabetes. METHODS: Data from a prospective cohort - the Coronary Artery Calcification in Type 1 Diabetes Study - were evaluated. Fibrinogen levels at baseline were separated into quartiles. CAC was measured twice and averaged at baseline and at follow-up 2.4+/-0.4 years later. CAC progressors were defined as participants whose square-root transformed CAC volume increased by >/=2.5mm(3) or development of clinical coronary artery disease during the follow-up period. RESULTS: Fibrinogen levels were higher in progressors than in non-progressors (276+/-61mg/dl versus 259+/-61mg/dl, p=0.0003). CAC progression, adjusted for known cardiovascular risk factors, increased in the highest quartile. CONCLUSIONS: Higher fibrinogen levels predict CAC progression in type 1 diabetes subjects, independent of standard cardiovascular risk factors. |
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Autoren:
Rodrigues TC
; Snell-Bergeon JK
; Maahs DM
; Kinney GL
; Rewers M
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Quelle:
Atherosclerosis. 2010 Jan 4.
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| Literaturrecherche: U.S.National Library of Medicine's PubMed® | |
 
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