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Ileal interposition with sleeve gastrectomy for control of type 2 diabetes.
BACKGROUND: Bariatric surgery offers the best solution in management of obesity and related metabolic ailments, paving the way for a concept termed metabolic surgery. We report the results of a novel surgical procedure on glycemic control and metabolic syndrome in poorly controlled type 2 diabetes. METHODS: Ten patients (four men, six women) underwent laparoscopic surgical procedure of sleeve gastrectomy and ileal interposition. All patients had diabetes for more than 3 years with poor control despite use of oral hypoglycemic agents (OHAs) and/or insulin. The primary outcome was remission of diabetes (hemoglobin A1c <7% without OHAs/insulin), and secondary outcomes were change in OHA requirement, components of metabolic syndrome, insulin resistance, and microalbuminuria. RESULTS: We report the preliminary postoperative follow-up data of 9.1 +/- 5.3 months (range, 2-16 months). Participants had a mean age of 48.2 +/- 9 years (range, 34-62 years), duration of diabetes of 11 +/- 5.7 years (range, 4-25 years), and preoperative body mass index of 33.8 +/- 6.5 kg/m(2). Seven patients had diabetes remission, and the remaining three showed significantly decreased OHA requirement. All participants had weight loss ranging between 15% and 30% and had remission of hypertension. Microalbuminuria (96.8 +/- 19.1 vs. 46.7 +/- 10.1 mg/L, P = 0.03568) and insulin resistance as assessed by homeostasis assessment model of insulin resistance (5.2 +/- 2.1 vs. 1.8 +/- 0.9, P = 0.0005) decreased significantly after surgery. CONCLUSIONS: Our preliminary observations demonstrated the feasibility, safety, and efficacy of this novel surgical procedure in type 2 diabetes. Further long-term data from more patients are necessary to confirm these findings. |
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Autoren:
Kumar, K V S Hari
; Ugale, Surendra
; Gupta, Neeraj
; Naik, Vishwas
; Kumar, Pawan
; Bhaskar, P
; Modi, K D
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Quelle:
Diabetes Technol Ther. 2009 Dec;11(12):785-9.
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| Literaturrecherche: U.S.National Library of Medicine's PubMed® | |
 
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